Washed microbiota transplantation improves the sleep quality in patients with inflammatory bowel disease

发表时间：2024-08-02 17:03
Posted at 17:03h in News by

There is scarce evidence to support the effectiveness of faecal microbiota transplantation (FMT) in improving sleep among individuals with inflammatory bowel disease (IBD). Our study aims to evaluate the effect of washed microbiota transplantation (WMT) (the new method of FMT) on the sleep of patients with IBD in short term. This prospective study was conducted as part of two interventional clinical trials (starting on February 2013 and expected to end on December 2025) and placed significant emphasis on evaluating sleep quality in patients with IBD. To measure subjective sleep, we used the Pittsburgh Sleep Quality Index (PSQI). The primary endpoint was the PSQI score one month after WMT.  This stage study included 52 eligible patients evaluated by PSQI questionnaire who underwent WMT from January 2020 to March 2021 and 47 patients were enrolled for analysis. The age of the patients ranged from 13 to 60 years, with a mean of 33.4 years, and 57.4% (25/47) of the patients were male. The PSQI score for all 47 patients one month after undergoing WMT was significantly lower (Cohen d = 0.59, p < 0.001) compared to the baseline. Moreover, baseline PSQI was correlated with the difference value of PSQI before and after WMT (post-PSQI minus pre-PSQI) (r = 0.61, p < 0.05), indicating that patients with poorer sleep quality at baseline might experience greater improvements after WMT. The study suggests that WMT might be a helpful intervention for improving the sleep quality of patients with IBD, encouraging clinicians to consider its use in clinical practice for addressing poor sleep in IBD patients.

Reference：Li Q, Liu Y, Zhang Z, Zhang S, Ding X, Zhang F. Washed Microbiota Transplantation Improves the Sleep Quality in Patients with Inflammatory Bowel Disease. Nat Sci Sleep. 2024 Aug 2;16:1141-1152. doi: 10.2147/NSS.S460882. PMID: 39109266; PMCID: PMC11302522.

First author：Qianqian Li  Yujie Liu

Corresponding author：Faming Zhang