Background Machine learning based on clinical data and treatment protocols for better clinical decision-making is a current research hotspot. This study aimed to build a machine learning model on washed microbiota transplantation (WMT) for ulcerative colitis (UC), providing patients and clinicians with a new evaluation system...
Background and Aim: Vitamin D (VD) deficiency was reported to correlate with ulcerative colitis (UC) activity, which might be closely related to gut microbiota dysbiosis. This study aims to investigate the effects of washed microbiota transplantation (WMT) on VD metabolism in UC. Methods: The serum levels...
In August 2024, our team first reported on the use of transendoscopic enteral tube (TET) for targeted ileal drug delivery to resolve massive fecal impaction in the small intestine in the international leading journal 《Endoscopy》. This is the third paper on TET technology published in...
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by skin thickening and fibrosis, which may involve multiple organs and systems. Recent studies have indicated that patients with SSc frequently exhibit gut microbiota dysbiosis, suggesting that the gut microbiota may play a role in the...
A 50-year-old man with a 15-year history of Crohn’s disease (CD) was urgently admitted due to abdominal distension, which had worsened over a week. In the preceding 3 months, he had undergone exclusive enteral nutrition. The abdominal distension persisted despite accepting symptomatic treatments such as fasting...
Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic approach for dysbiosis-related diseases. However, the clinical practice of crude fecal transplants presents limitations in terms of acceptability and reproductivity. Consequently, two alternative solutions to FMT are developed: transplanting bacteria communities or virome. Advanced methods...
Clostridioides difficile infection (CDI) is one of the most common healthcare-associated and community-acquired infections, posing a serious public health challenge due to the increase of morbidity, mortality, and medical costs. Antibiotic therapies are effective for the first episode of CDI in some patients, while the...
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain and changes in bowel habits. In addition to gastrointestinal symptoms, about 40% of patients with IBS also show a variety of extraintestinal symptoms, especially sleep disorders, anxiety and depression, which further...
The crucial role of gut microbiota in ulcerative colitis (UC) makes microbial manipulation an attractive treatment for UC. Increasing evidence from randomized controlled trials has suggested that fecal microbiota transplantation (FMT) is an effective and safe treatment for active UC. However, the underlying mechanisms and...
Abstract: The emerging microbiota technologies, especially the sequencing technologies of microbiome, multi-omics approaches, and the new methods of fecal microbiota transplantation, have promoted the revolutionary development of medicine. These technologies have been used in clinical diagnosis and therapy for many diseases among the multiple traditional disciplines....