Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic approach for dysbiosis-related diseases. However, the clinical practice of crude fecal transplants presents limitations in terms of acceptability and reproductivity. Consequently, two alternative solutions to FMT are developed: transplanting bacteria communities or virome. Advanced methods...
Clostridioides difficile infection (CDI) is one of the most common healthcare-associated and community-acquired infections, posing a serious public health challenge due to the increase of morbidity, mortality, and medical costs. Antibiotic therapies are effective for the first episode of CDI in some patients, while the...
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain and changes in bowel habits. In addition to gastrointestinal symptoms, about 40% of patients with IBS also show a variety of extraintestinal symptoms, especially sleep disorders, anxiety and depression, which further...
The crucial role of gut microbiota in ulcerative colitis (UC) makes microbial manipulation an attractive treatment for UC. Increasing evidence from randomized controlled trials has suggested that fecal microbiota transplantation (FMT) is an effective and safe treatment for active UC. However, the underlying mechanisms and...