A 50-year-old man with a 15-year history of Crohn’s disease (CD) was urgently admitted due to abdominal distension, which had worsened over a week. In the preceding 3 months, he had undergone exclusive enteral nutrition. The abdominal distension persisted despite accepting symptomatic treatments such as fasting...
Background: Both infliximab (IFX) and fecal microbiota transplantation (FMT) have shown the efficacy for inflammatory bowel disease (IBD). However, there has no head-to-head study on the cost-value of the such treatments on IBD. This study aimed to compare the medical costs using IFX and the new...
Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic approach for dysbiosis-related diseases. However, the clinical practice of crude fecal transplants presents limitations in terms of acceptability and reproductivity. Consequently, two alternative solutions to FMT are developed: transplanting bacteria communities or virome. Advanced methods...
Clostridioides difficile infection (CDI) is one of the most common healthcare-associated and community-acquired infections, posing a serious public health challenge due to the increase of morbidity, mortality, and medical costs. Antibiotic therapies are effective for the first episode of CDI in some patients, while the...
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain and changes in bowel habits. In addition to gastrointestinal symptoms, about 40% of patients with IBS also show a variety of extraintestinal symptoms, especially sleep disorders, anxiety and depression, which further...
The crucial role of gut microbiota in ulcerative colitis (UC) makes microbial manipulation an attractive treatment for UC. Increasing evidence from randomized controlled trials has suggested that fecal microbiota transplantation (FMT) is an effective and safe treatment for active UC. However, the underlying mechanisms and...
Abstract: The emerging microbiota technologies, especially the sequencing technologies of microbiome, multi-omics approaches, and the new methods of fecal microbiota transplantation, have promoted the revolutionary development of medicine. These technologies have been used in clinical diagnosis and therapy for many diseases among the multiple traditional disciplines....
Abstract The limitation of traditional delivery methods for fecal microbiota transplantation (FMT) gave birth to colonic transendoscopic enteral tubing (TET) for addressing the requirement of frequent FMTs. Colonic TET as a novel endoscopic intervention has received increasing attention in practice since 2015 in China. Emerging studies...
Abstract Cryptosporidium infection is a worldwide disease caused by intracellular protozoan parasite Cryptosporidium,which can disrupt gut epithelial barrier and contribute to mild or severe diarrhea. Emerging evidence demonstrates that fecal microbiota transplantation (FMT) is an effective strategy for microbiota-related diseases by reconstructing gut microbiota. The new...
Fecal microbiota transplantation (FMT) has been used as a core therapy for treating dysbiosis-related diseases by remodeling gut microbiota. The methodology and technology for improving FMT are stepping forward, mainly including washed microbiota transplantation (WMT), colonic transendoscopic enteral tubing (TET) for microbiota delivery, and purified...